Summary

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondrial-derived peptide known as an "exercise mimetic" for its ability to regulate metabolic homeostasis. It targets skeletal muscle to enhance glucose metabolism and insulin sensitivity, functioning similarly to AICAR by activating the AMPK pathway. Research focuses on its potential to combat metabolic dysregulation, obesity, and age-related physical decline. For research use only—not for human consumption.

Clinical Data

Animal studies reveal that MOTS-c administration significantly prevents age-associated and high-fat-diet-induced insulin resistance. In mice fed a high-fat diet, MOTS-c treatment prevented fat gain and improved glucose tolerance to levels comparable to lean controls. Notably, older mice treated with MOTS-c demonstrated a two-fold increase in running capacity and physical performance, suggesting a restoration of cellular metabolic function. Investigations into cellular mechanisms show that MOTS-c promotes fatty acid oxidation and increases glucose uptake in myotubes, confirming its role as a potent regulator of cellular energy balance.