Summary

Melanotan 2 is a synthetic cyclic lactam analogue of naturally occurring alpha-melanocyte-stimulating hormone (α-MSH). It acts as a non-selective agonist of the melanocortin receptors (MC1, MC3, MC4, and MC5), primarily known for stimulating melanogenesis (skin pigmentation) and influencing lipid metabolism and sexual function. It is utilized in research settings to explore the melanocortin system’s role in physiological regulation. For research use only—not for human consumption.

Clinical Data

In preclinical trials, Melanotan 2 has displayed potent melanogenic activity, stimulating the production of eumelanin in melanocytes significantly faster than UV exposure alone. Rodent studies involving diet-induced obesity have observed that activation of the MC4 receptor by Melanotan 2 results in immediate appetite suppression, increased metabolic rate, and rapid weight loss. Furthermore, research into sexual dysfunction has shown that subcutaneous administration in rat models induces erectile activity via central nervous system mechanisms, distinct from vascular-acting agents. Common adverse effects noted in trial subjects include transient nausea and facial flushing.