Summary

TB500 is a synthetic peptide derived from a fragment of the naturally occurring protein thymosin beta-4 (TB4), which plays a key role in tissue repair and regeneration within the body. TB500 mimics the active region of TB4 responsible for promoting cell migration, angiogenesis (formation of new blood vessels), and modulating inflammation, thus accelerating healing in muscles, tendons, skin, and other tissues. Originally developed for veterinary uses such as racehorse recovery, TB500 is primarily utilised for injury repair and flexibility enhancement due to its broad-acting regenerative properties. For research use only—not for human consumption.

Clinical Data

A notable preclinical study found that treatment with thymosin beta-4 (the parent compound of TB500) accelerated wound closure rates by up to 43% in a rat full-thickness wound model, demonstrating enhanced cell migration, angiogenesis, and faster tissue regeneration compared to controls. Another cited statistic from research in animal models indicates significantly increased muscle cell repair and reduced healing timelines following acute injury with TB500 administration, supporting its reputation for speeding injury recovery in musculoskeletal tissues. Large-scale human studies remain limited, but these results suggest meaningful benefits in injury repair based on experimental data.